I have 3 examples I would like to share:
1) I had a doe pronghorn antelope tag. On the ranch I hunt, it is very difficult to get close for various reasons. We spotted a buck and two does across a wide draw. The shooting conditions were close to perfect as you get. It was overcast with no mirage. As I was setting up to shoot, there was a 2 mph wind blowing straight into my face. My rangefinder consistently showed 738 yards, 13.5 moa elevation, with 0.5 moa left hold off. I was shooting my 6 CM with a 109 ELD-M. I could tell the doe was slightly quartering towards me, and watching me intently. POI was slightly behind the shoulder. I'm not sure if she was quartering more than I thought, or the bullet turned slightly on impact. The bullet hit the center of the near lung, exited the rear of the lung, tore the liver in half, and exited the off-side flank. The does walked slowly about 10 yards, reared up and fell dead.
2) My wife elected to hunt from a blind. It was positioned about 200 yards from a stock pond. When a herd of does tried to come in to drink, the rutting herd buck pushed the does away from the water. The herd moved past her blind. The buck stopped about 160 yards from her, and stared at the blind. She had a 15 mph right to left wind. The buck was facing to her left and broadside. She was shooting her trusty little 6BR with a 95 gr Berger Classic Hunter. The bullet hit the front of the shoulders at the base of the neck and exited. He dropped in his tracks.
3) Last was my elk hunt in northern New Mexico. My guides spotted a big-bodied six point bull across a canyon. It was getting late. The conditions were dead calm. I ranged him at 694 yards. I was using my 6.5-284 with 140 gr Berger Elite Hunters. The rangefinder showed 11.25 moa elevation with no hold-off. The bull was slightly quartering away and slightly below my position. He was grazing when I shot. The bullet hit him slightly high behind the right shoulder, and probably angled downward towards his brisket. The bullet did not exit. He turned, stumbled down hill a few steps and went down. It was dark when the guides field dressed him. His chest cavity was blood soup. Because of the circumstances, no bullet was found.
FWIW,
Steve